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Relationship of Preinjury Depressive Symptoms to Outcomes 3 Months After Complicated and Uncomplicated Traumatic Brain Injury

Posted By Bernadette M. Rensing (Colvin), Monday, July 14, 2014
Updated: Friday, July 11, 2014

Dr.John Whyte interviews Dr. Angelle Sander, author of the article entitled "Relationship of Preinjury Depressive Symptoms to Outcomes 3 Months After Complicated and Uncomplicated Traumatic Brain Injury."

OBJECTIVE: This study examines the effect of preinjury depressive symptoms on outcomes 3 mos after complicated and uncomplicated cases of mild traumatic brain injury.

DESIGN: Preinjury depressive symptoms, experienced in the 30 days before injury, as measured by retrospective self-report, were assessed within the first 2 wks after injury. The outcome measures assessed at 3 mos after injury included affective/behavioral, cognitive, and physical problems and health-related quality-of-life.

RESULTS: There were 177 patients who completed both the baseline and 3-mo follow-up interviews. The sample was categorized by severity of depressive symptoms in the month before injury as normal, mild, or moderate-severe. Compared with those reporting no preinjury depressive symptoms, persons reporting moderate-severe depressive symptoms had significantly worse outcomes on the Affective and Behavioral and the Cognitive subscales of the Head Injury-Family Interview Problem Checklist and on the 36-item Short-Form Health Survey Mental Component Summary score. The group reporting mild preinjury depressive symptoms scored worse on a measure of cognitive symptoms compared with those with no preinjury depressive symptoms. There was no interaction between preinjury depressive symptoms and severity of the mild traumatic brain injury (complicated or uncomplicated) for any of the outcomes.

CONCLUSION: Moderate to severe depressive symptoms in the month before injury seems to be a possible risk factor for poor affective/behavioral, cognitive, and mental health-related quality-of-life outcomes at 3 mos after mild traumatic brain injury. Clinicians and researchers should consider the impact of preinjury depression on the recovery process to provide at-risk patients adequate treatment soon after injury. were no differences in magnetic resonance imaging scores. Satisfaction was high; there were no adverse events.

Dr. Angelle Sander is Associate Professor and Director of the Division of Neuropsychology and Rehabilitation Psychology at Baylor College of Medicine and the Director of TIRR Memorial Hermann’s Brain Injury Research Center. She is the Project Director for the NIDRR-funded Rehabilitation Research and Training Center on Developing Strategies to Foster Community Integration and Participation for Individuals with TBI, Co-Project Director for the TBI Model System of TIRR, and Co-PI on a newly funded randomized controlled trial of Donepezil to improve functional memory after TBI. Dr. Sander has served as PI for randomized controlled trials on brief intervention for substance abuse following TBI and contextualized memory strategy training in persons with TBI. Specialty areas include family adjustment to TBI, cognitive rehabilitation, improving community participation of persons with TBI, intimacy and sexuality after TBI, assessing and treating substance abuse in persons with TBI, and racial/ethnic diversity in outcomes.

A PDF transcript of the podcast is available for download by selecting the attached file below.

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Tags:  depression  Sander  TBI  traumatic brain injury  Whyte 

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